Expanding the Role Repertoire While Aging: A Drama Therapy Model

Expanding the prion disease repertoire.

In 1982, Stanley Prusiner proposed that the infectious agent of transmissible spongiform encephalopathies (TSEs), a group of relatively rare neurodegenerative disorders that includes Creutzfeldt–Jakob disease and scrapie, lacks replicating nucleic acids and instead is composed primarily of a misfolded conformation of the prion protein, which he termed PrP (1). Originally, the “prion” hypothesis...

The Expanding Role of Vital Pulp Therapy.

The expanding repertoire of circular RNAs.

I n recent years, reports suggesting a process of exon shuffling and the generation of circular RNAs have not gained wide support because they are inconsistent with the established dogma of linear exon splicing. This debate has now come full circle with evidence proving more definitively the existence of circular RNAs in two recent articles published in the 21 March issue of Nature. These artic...

Expanding the Regulatory Repertoire of GEFs

Small GTPases comprise a large and heterogeneous group of regulatory proteins that act throughout the cell as on/off switches, orchestrating processes as diverse as endocytosis at the plasma membrane to protein export from the nucleus. GTPases themselves are controlled by proteins called guanine nucleotide exchange factors (GEFs). Upon binding a GEF, the GTPase releases a molecule of GDP and pi...

Expanding NEURON's Repertoire of Mechanisms with NMODL

Neuronal function involves the interaction of electrical and chemical signals that are distributed in time and space. The mechanisms that generate these signals and regulate their interactions are marked by a rich diversity of properties that precludes a "one size fits all" approach to modeling. This article presents a summary of how the model description language NMODL enables the neuronal sim...